Treatment Options
Prospective Treatment Options
Antibiotic therapy
Carbapenems are effective antibiotics for the treatment of A. baumannii infections, but
there has been a progressive increase in the rate of resistance to carbapenems in A.
baumannii. Only a few effective antibiotic options are available for the treatment of
drug-resistant A. baumannii infections. Against extensively resistant A.
baumannii,
combination antibiotic therapies can now be investigated and applied.
Non-antibiotic therapy
- Phage therapy
- Antibody therapy
- Targeted quorum sensing therapy
Despite being known for its relatively low virulence, multi-drug resistant A.
baumannii infections pose a significant threat to patients. Due to the increasing clinical importance
of A. baumannii, the number of studies on A. baumannii is increasing dramatically. As our
current arsenal of antimicrobial drugs becomes less effective in treating A. baumannii infections, there is
increasing pressure to find new targets for new therapies to address incurable bacterial infections.
In short, we need to discover new classes of antibiotics. We can successfully control A. baumannii
infections if we continue to make every effort to maintain the effectiveness of antibiotics and develop
novel antibiotics. At Ace Therapeutics, we discuss some new therapeutic approaches that deserve further study.
We look forward to having you on board to develop the next generation of antimicrobial treatments for A.
baumannii.
References
- Lee C-R, et al. Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance
Mechanisms, and Prospective Treatment Options. Frontiers in Cellular and Infection Microbiology,
2017,7:55.
- Kyriakidis I, et al. Acinetobacter baumannii Antibiotic Resistance Mechanisms.
Pathogens, 2021, 10, 373.
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