Salmonellae
Salmonellae are a part of the Enterobacteriaceae clan, characterized by their gram-negative nature. They are also known as enterobacteria. One can find close to a thousand species (also known as strains) in existence. They are renowned for their widespread presence in food products, and are often culprits in foodborne illnesses. Under the microscope, these pathogens resemble short rods. They are resilient and adaptable organisms, able to withstand variable conditions such as fluctuating temperatures, levels of humidity and pH. They can retain their vitality in water for a period stretching from 2 to 3 weeks, and even in processed meat for 2 to 3 months. It is at 37 degrees that they exhibit their best reproductive prowess.
A Look into Epidemiology Salmonellosis
- Salmonslosis is an illness triggered by Salmonella bacteria. The typical symptoms associated with it include acute fever, abdominal discomfort, diarrhea, nausea, with occasional instances of vomiting.
- The primary mode of transmission is via the fecal-oral route. Infections are usually triggered by consumption of food items that are contaminated, especially foods like eggs, poultry, typical dairy like milk and other fruits and vegetables contaminated with fecal matter.
- Those considered high-risk are primarily young children (those under 5), the elderly and those with compromised immune systems.
Antimicrobial Resistance
Facing Salmonella drug resistance involves mechanisms such as,
- Expulsion of the drug from the bacteria
- Variation in the permeability of the cell membrane
- The bacterial action of enzymatically breaking down antimicrobial drugs
- Changing the target site of the drug's action
- Resistance mediated-by-mobile elements
Potential Treatment Options
Antibiotics have been a successful treatment measure for Salmonella infections. However, inappropriate use of these antibiotics have caused resistance in Salmonella, becoming an increasing issue. With that, there is an essential need to explore alternate therapies. Other treatment avenues include
- Utilizing phage therapy
- Making use of Immunomodulators
- Introducing newly developed antimicrobial agents
Our Expertise
Ace Therapeutics is an organization committed to understanding the complications surrounding Salmonella. Our focus is to study the Salmonella resistance mechanisms and uncover new potential targets. As part of our services we offer,
We offer detailed whole genome sequence analysis using cutting-edge sequencing techniques. With this, we perform extensive analysis of Salmonella, allowing us to pinpoint genetic markers chalked up to antibiotic resistance.
Our dedicated teams in pharmaceutical research are working tirelessly to search for compounds that can effectively target Salmonella, thus minimizing the probability of resistance.
Our developmental vaccines aim to trigger strong immune responses against superbugs which could lead to long-term protection and reduction in infection loads.
Summing Up
Salmonellae continue to be a consistent danger to global health. The difficulties presented by antibiotic resistance call for continual research and innovation. Ace Therapeutics is staunchly dedicated to broadening the understanding of Salmonella biology, as well as creating new treatment approaches. We welcome queries for more in-depth information about our research. Ace Therapeutics is eager to explore any shared work opportunities, all in the interest of a healthier tomorrow!
Reference
- Threlfall EJ. (2002). Antimicrobial drug resistance in Salmonella: problems and perspectives in food- and water-borne infections. FEMS Microbiol Rev. 26(2):141-148.